Exploring the connection between specific genes and Lewy Body Dementia
Intersection of GBA and LRRK2 in Lewy Body Dementia
This study is looking at how changes in a specific gene might play a role in Lewy Body Dementia, and if you have LBD or are at risk, you can help by sharing samples to better understand these genetic links and find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-11138659 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to Lewy Body Dementia (LBD), particularly focusing on the GBA1 gene, which has been identified as a significant risk factor. The study aims to understand how mutations in this gene may lead to the development of LBD and its associated neuropathology. By examining the cellular mechanisms involved, the research seeks to uncover potential pathways that could be targeted for therapeutic interventions. Patients with LBD or those at risk may provide biological samples to help elucidate these genetic connections.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals diagnosed with Lewy Body Dementia or those with a family history of related neurodegenerative diseases.
Not a fit: Patients with other forms of dementia that do not involve the genetic factors being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for Lewy Body Dementia.
How similar studies have performed: Previous research has shown promising results in understanding genetic influences on neurodegenerative diseases, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Lavoie, Matthew J — University of Florida
- Study coordinator: Lavoie, Matthew J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.