Exploring the complexity of bacterial genomes
Official title: Unexpected complexity in bacterial genomes
Funded at Wadsworth Center · NIH-11012382 · Data updated 2026-11-12
This study is exploring how bacteria use their genes in surprising ways, which could help us understand them better and improve treatments for bacterial infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wadsworth Center NIH-funded |
| Lab location | 1 site (Menands, United States) |
| Project start | February 1, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $534,040 |
| NIH project number | 5R35GM144328-04 |
| Project ID | NIH-11012382 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with bacterial infections or those interested in the genetic mechanisms of bacteria.
✕Less likely to help
Patients with viral infections or non-bacterial related conditions may not receive any benefit from this research.
What this research studies
This research investigates the intricate nature of bacterial genomes, focusing on how genes are transcribed and regulated. It challenges the traditional view that genes are discrete entities, revealing that many promoters are located within genes themselves, leading to the production of non-coding RNAs. By utilizing advanced techniques in genetics and molecular biology, the research aims to uncover the mechanisms of pervasive transcription and its implications for gene expression. Patients may benefit from a deeper understanding of bacterial behavior, which could inform treatments for bacterial infections.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for managing bacterial infections and enhancing antibiotic efficacy.
How similar studies have gone: Previous research has shown promising results in understanding bacterial gene regulation, suggesting that this approach could yield significant insights.
Where this research is happening
-
Wadsworth Center
Menands, United States Active
Researchers
- Principal investigator: Wade, Joseph Thomas — Wadsworth Center
- Study coordinator: Wade, Joseph Thomas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.