NIH-funded research R01 grant

Exploring the causes of early COPD

Official title: Understanding the Origins of Early COPD

Funded at Univ of Massachusetts Med Sch Worcester · NIH-11180772 · Data updated 2026-11-12

This study is looking at the early changes in the lungs that can lead to COPD, using advanced imaging to find out who might be at risk for more serious problems, and it’s for anyone who wants to help us understand how to stop COPD from getting worse.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniv of Massachusetts Med Sch Worcester
NIH-funded
Lab location1 site (Worcester, United States)
Project startAugust 31, 2024
Project endApril 30, 2026
Funding year2024
Award (this year)$2,168,770
NIH project number7R01HL144718-06
Project IDNIH-11180772 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include younger smokers who may be at risk for developing COPD.

Less likely to help

Patients with advanced COPD or those who do not smoke may not benefit from this research.

What this research studies

This research investigates the early biological processes that lead to Chronic Obstructive Pulmonary Disease (COPD), focusing on small airway abnormalities that can be detected through advanced imaging techniques. By analyzing immune responses and airway surface liquid, the study aims to identify individuals at risk of developing more severe forms of the disease. Participants will undergo noninvasive assessments to track disease progression and understand the underlying mechanisms that could be targeted for future therapies. The goal is to develop strategies to halt the progression of COPD before it becomes irreversible.

Why it matters

Potential benefit: If successful, this research could lead to new therapies that modify the course of COPD, improving outcomes for patients.

How similar studies have gone: Other research has shown promise in understanding early COPD pathology, but this approach is innovative in its focus on noninvasive detection and immune response analysis.

Where this research is happening

  • Univ of Massachusetts Med Sch Worcester
    Worcester, United States
    Active

Researchers

  • Principal investigator: Martinez, Fernando J — Univ of Massachusetts Med Sch Worcester
  • Study coordinator: Martinez, Fernando J

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.