Exploring the causes of cognitive decline in Lewy body diseases
Understanding biomarkers of cognitive decline in Lewy body diseases
['FUNDING_R37'] · UNIVERSITY OF PENNSYLVANIA · NIH-10878353
This study is looking at how certain biological markers are linked to memory and thinking problems in people with Lewy body diseases, like Parkinson's and Lewy body dementia, to find new ways to help improve their care and quality of life.
Quick facts
| Phase | ['FUNDING_R37'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10878353 on ClinicalTrials.gov |
What this research studies
This research investigates the biological markers associated with cognitive decline in patients with Lewy body diseases, such as Parkinson's disease and dementia with Lewy bodies. By examining the differences in clinical symptoms and outcomes among these patients, the study aims to uncover the molecular factors that contribute to cognitive decline. The researchers will utilize biomarker screening and model systems to identify potential therapeutic targets that could improve patient care and quality of life. This approach not only seeks to understand the disease better but also aims to pave the way for new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy body diseases, such as Parkinson's disease with or without dementia, and dementia with Lewy bodies.
Not a fit: Patients with cognitive decline due to other non-Lewy body related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients experiencing cognitive decline due to Lewy body diseases.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for cognitive decline in related conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN-PLOTKIN, ALICE S — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: CHEN-PLOTKIN, ALICE S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's disease and related dementia, Alzheimer's disease and related disorders, Alzheimer's disease or a related dementia, Alzheimer's disease or a related disorder, Alzheimer's disease or related dementia