Exploring the causes and biology of colorectal cancer using protein data
Official title: Uncovering colorectal cancer etiology and biology by integrating proteomics with other omics data
Funded at Vanderbilt University Medical Center · NIH-11052589 · Data updated 2026-11-12
This study is looking at how our genes and proteins might affect the risk of colorectal cancer, using samples from 300 people to help find better ways to prevent and treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project start | April 11, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $723,688 |
| NIH project number | 5R01CA269589-03 |
| Project ID | NIH-11052589 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a family history of colorectal cancer or those at high genetic risk for the disease.
✕Less likely to help
Patients who do not have a genetic predisposition to colorectal cancer or those with advanced-stage cancer may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to colorectal cancer (CRC) by integrating proteomics with other omics data. It aims to identify proteins associated with CRC risk through a comprehensive analysis of normal colon tissues from 300 subjects. By generating extensive proteomics and genomics data, the study seeks to build predictive models that can enhance our understanding of how these proteins influence tumor progression and cellular functions. Patients may benefit from insights that could lead to improved prevention and treatment strategies for CRC.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment options for colorectal cancer patients.
How similar studies have gone: Previous research has shown success in identifying genetic factors related to colorectal cancer, but this approach integrating proteomics is relatively novel.
Where this research is happening
-
Vanderbilt University Medical Center
Nashville, United States Active
Researchers
- Principal investigator: Guo, Xingyi — Vanderbilt University Medical Center
- Study coordinator: Guo, Xingyi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.