Exploring the brain mechanisms of depression in Parkinson's disease

Who could benefit from this research

What this research studies

This research investigates the unique neural mechanisms underlying depression in patients with Parkinson's disease (dPD). It aims to identify specific synaptic and network-level changes in the brain that contribute to depression, which often occurs before motor symptoms in Parkinson's. Using advanced imaging techniques like PET and fMRI, the study will compare brain activity and structure in individuals with dPD, those with Parkinson's without depression, individuals with major depressive disorder, and healthy controls. The goal is to uncover new treatment targets that could lead to more effective therapies for depression in Parkinson's disease.

Why it matters

Where this research is happening

• Yale University
  New Haven, United States Active

Researchers

• Principal investigator: Holmes, Sophie — Yale University
• Study coordinator: Holmes, Sophie

Related research

Other NIH-funded projects on the same topics.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.