Exploring the brain mechanisms of depression in Parkinson's disease
Identifying and targeting the neural basis of depression in Parkinson's disease
['FUNDING_R01'] · YALE UNIVERSITY · NIH-11014387
This study is looking at how depression affects the brains of people with Parkinson's disease to find out what’s happening in their brains and help create better treatments for them.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-11014387 on ClinicalTrials.gov |
What this research studies
This research investigates the unique neural mechanisms underlying depression in patients with Parkinson's disease (dPD). It aims to identify specific synaptic and network-level changes in the brain that contribute to depression, which often occurs before motor symptoms in Parkinson's. Using advanced imaging techniques like PET and fMRI, the study will compare brain activity and structure in individuals with dPD, those with Parkinson's without depression, individuals with major depressive disorder, and healthy controls. The goal is to uncover new treatment targets that could lead to more effective therapies for depression in Parkinson's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who also experience symptoms of depression.
Not a fit: Patients with Parkinson's disease who do not experience depression or those with other unrelated mental health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted treatments for depression in Parkinson's disease, improving quality of life for affected patients.
How similar studies have performed: Previous research has shown promising results in identifying brain mechanisms related to depression, suggesting that this approach could yield valuable insights.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HOLMES, SOPHIE — YALE UNIVERSITY
- Study coordinator: HOLMES, SOPHIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.