Exploring the 3D structure of chromatin in brain cells
Center for Integrated Multi-modal and Multi-scale Nucleome Research
This study is looking at how the way DNA is organized in brain cells affects how genes work, and it's for anyone interested in understanding more about brain function and gene expression in humans and other animals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10880637 on NIH RePORTER |
What this research studies
This research investigates how the 3D arrangement of chromatin within the nucleus affects gene expression in different cell types, particularly in the brain. By utilizing advanced imaging techniques and genomic methods, the team aims to create detailed reference maps of chromatin architecture in mouse, macaque, and human brains. The study will also involve experiments to understand how changes in chromatin structure influence gene regulation. Ultimately, the findings will provide valuable tools and resources for the scientific community to further explore the complexities of gene expression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological conditions or those interested in the genetic basis of brain function.
Not a fit: Patients with conditions unrelated to chromatin architecture or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation and potential therapeutic strategies for neurological disorders.
How similar studies have performed: Previous research has shown promise in understanding chromatin dynamics, but this approach aims to provide unprecedented detail and is considered innovative.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Ren, Bing — University of California, San Diego
- Study coordinator: Ren, Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.