Exploring small RNA roles in gonorrhea bacteria
Generation and characterization of a small RNA mutant library in Neisseria gonorrhea
['FUNDING_R03'] · OHIO UNIVERSITY ATHENS · NIH-11039008
This study is looking at tiny molecules in the gonorrhea-causing bacteria to see how they help the bacteria survive and resist antibiotics, which could lead to new ways to treat infections for people affected by gonorrhea.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO UNIVERSITY ATHENS (nih funded) |
| Locations | 1 site (ATHENS, UNITED STATES) |
| Trial ID | NIH-11039008 on ClinicalTrials.gov |
What this research studies
This research investigates the role of small regulatory RNAs (sRNAs) in the bacteria Neisseria gonorrhoeae, which causes gonorrhea, a common sexually transmitted infection. The study aims to create a comprehensive annotation of sRNA genes to better understand their functions and how they contribute to antibiotic resistance. By analyzing existing RNA sequencing data, the researchers will identify and prioritize sRNAs that may play critical roles in the bacteria's ability to survive and cause infection. This work could lead to new therapeutic strategies to combat antibiotic-resistant strains of gonorrhea.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with gonorrhea, especially those experiencing treatment failures due to antibiotic resistance.
Not a fit: Patients who do not have gonorrhea or those with other unrelated infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for gonorrhea, particularly against antibiotic-resistant strains.
How similar studies have performed: While the study of sRNAs in bacterial pathogens is emerging, this specific approach to understanding sRNAs in Neisseria gonorrhoeae is relatively novel and has not been extensively tested.
Where this research is happening
ATHENS, UNITED STATES
- OHIO UNIVERSITY ATHENS — ATHENS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARROLL, RONAN — OHIO UNIVERSITY ATHENS
- Study coordinator: CARROLL, RONAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.