Exploring small proteins in Mycobacteria
Official title: Systematic Discovery and Analysis of Small Proteins and Small ORFs in Mycobacteria
Funded at Wadsworth Center · NIH-10663206 · Data updated 2026-11-12
This study is exploring tiny proteins in Mycobacteria that are usually ignored, hoping to uncover their roles in health and disease, which could eventually help develop new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wadsworth Center NIH-funded |
| Lab location | 1 site (Menands, United States) |
| Project start | August 1, 2020 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $546,967 |
| NIH project number | 5R01GM139277-04 |
| Project ID | NIH-10663206 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with infections caused by Mycobacteria or those interested in genetic and molecular biology.
✕Less likely to help
Patients with conditions unrelated to Mycobacteria or those not interested in molecular biology may not receive any benefit from this research.
What this research studies
This research investigates the discovery and functional analysis of small proteins and small open reading frames (ORFs) in Mycobacteria, which are often overlooked due to a bias towards larger genes in molecular biology. By utilizing advanced genomic sequencing and mass spectrometry techniques, the study aims to identify and characterize these small proteins, which may play significant roles in biological processes. The research will focus on understanding the functions of these small proteins, potentially leading to new insights in molecular biology and infectious diseases. Patients may benefit from the findings as they could lead to novel therapeutic targets or strategies.
Why it matters
Potential benefit: If successful, this research could uncover new therapeutic targets for treating infections caused by Mycobacteria.
How similar studies have gone: While the exploration of small proteins is a relatively novel area, there have been some successful findings in related fields that suggest potential for breakthroughs.
Where this research is happening
-
Wadsworth Center
Menands, United States Active
Researchers
- Principal investigator: Derbyshire, Keith M — Wadsworth Center
- Study coordinator: Derbyshire, Keith M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.