Exploring small nucleolar RNAs in cancer treatment
Official title: Systematic Characterization of Small Nucleolar RNAs in Cancer
Funded at Indiana University Indianapolis · NIH-10919834 · Data updated 2026-11-12
This study is looking at tiny molecules called snoRNAs in breast cancer to see how they might help doctors find better ways to diagnose and treat the disease, which could lead to new treatments that work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $386,764 |
| NIH project number | 5R01CA262623-04 |
| Project ID | NIH-10919834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include patients diagnosed with breast cancer or other cancers associated with the identified snoRNAs.
✕Less likely to help
Patients with cancers not linked to the snoRNAs being studied may not receive any benefit from this research.
What this research studies
This research investigates the role of small nucleolar RNAs (snoRNAs) in various types of cancer, particularly breast cancer. By analyzing patient samples, the team has identified snoRNAs that may serve as biomarkers and therapeutic targets. The study aims to understand how these snoRNAs contribute to cancer progression and drug resistance, potentially leading to new treatment strategies. Patients may benefit from improved diagnostics and targeted therapies based on the findings.
Why it matters
Potential benefit: If successful, this research could lead to the development of new biomarkers and therapies that improve cancer treatment outcomes.
How similar studies have gone: Previous research has shown promise in targeting RNA molecules for cancer treatment, suggesting potential success for this novel approach.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Han, Leng — Indiana University Indianapolis
- Study coordinator: Han, Leng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.