Exploring safer nicotine options for smokers who want to quit

Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers

NIH-funded research University of Pennsylvania · NIH-11061913

This study is looking at whether switching from regular cigarettes to options like e-cigarettes and nicotine pouches can help adult smokers lower their health risks, and it aims to find out what helps or hinders this change.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Pennsylvania NIH-funded
Lab location1 site (Philadelphia, United States)
Project IDNIH-11061913 on NIH RePORTER

What this research studies

This research investigates the potential of alternative nicotine delivery systems, such as e-cigarettes and oral nicotine pouches, as tools to help adult cigarette smokers reduce their health risks. The study aims to understand whether persistent smokers can successfully switch from traditional combustible cigarettes to these less harmful products. It will also explore the factors that influence this transition, providing insights into how to better support smokers in their quitting journey.

Who could benefit from this research

Good fit: Ideal candidates for this research are adult smokers who are looking to quit but have struggled with traditional cessation methods.

Not a fit: Patients who do not smoke or who have successfully quit smoking may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide smokers with safer alternatives to traditional cigarettes, potentially reducing smoking-related health risks.

How similar studies have performed: Previous research has shown that alternative nicotine delivery systems can be effective for some smokers, indicating promise for this approach.

Where this research is happening

Philadelphia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.