Exploring patient-supported methods for prenatal gene editing
PaSAGE: PAtient Supported Approaches to Gene Editing
This study is exploring new ways to safely edit genes before a baby is born to help prevent genetic diseases, while also making sure to listen to the thoughts and feelings of families affected by these technologies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Jacksonville NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project ID | NIH-10889169 on NIH RePORTER |
What this research studies
This research investigates new approaches to prenatal genetic editing, focusing on how to effectively disrupt disease mechanisms or eliminate disease-causing mutations before birth. It emphasizes the importance of including patient and family perspectives in the governance and ethical discussions surrounding these advanced technologies. By addressing the gaps in current governance structures, the research aims to create a framework that ensures safety and ethical considerations are prioritized in clinical practice. The study will engage with stakeholders to gather insights and develop guidelines that reflect the values and concerns of those directly affected.
Who could benefit from this research
Good fit: Ideal candidates for this research include expectant parents or families with a history of genetic conditions who are considering prenatal interventions.
Not a fit: Patients who are not expecting a child or do not have a family history of genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more ethically sound practices in prenatal gene editing, potentially preventing genetic diseases in future generations.
How similar studies have performed: While the approach of integrating patient perspectives into gene editing governance is relatively novel, there have been successful initiatives in other areas of genetic research that emphasize stakeholder engagement.
Where this research is happening
Jacksonville, United States
- Mayo Clinic Jacksonville — Jacksonville, United States (Active)
Researchers
- Principal investigator: Allyse, Megan a. — Mayo Clinic Jacksonville
- Study coordinator: Allyse, Megan a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.