Exploring pain sensitivity and new treatment targets using mice
Using mouse pain scales to discover unusual pain sensitivity and new pain targets
This study is looking at how genetic differences in mice can change how they feel pain, which might help us learn more about pain in people, and it aims to find new ways to treat pain without using addictive medications.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10581160 on NIH RePORTER |
What this research studies
This research investigates how genetic differences in mice can affect their sensitivity to pain, which may help us understand similar variations in humans. By developing automated pain scales that utilize high-speed videography and machine learning, the researchers aim to quantify pain responses in mice, making it easier to identify new genetic targets for pain treatment. The study focuses on understanding the transition from acute to chronic pain and seeks to find non-addictive therapeutic options by targeting specific genes in pain-sensing neurons.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic pain conditions that may have a genetic component.
Not a fit: Patients with acute pain that is not expected to transition to chronic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new, non-addictive pain treatments tailored to individual genetic profiles.
How similar studies have performed: Previous research has shown promise in using genetic approaches to understand pain sensitivity, but this specific automated pain assessment method is relatively novel.
Where this research is happening
New York, United States
- Columbia Univ New York Morningside — New York, United States (Active)
Researchers
- Principal investigator: Abdus-Saboor, Ishmail John — Columbia Univ New York Morningside
- Study coordinator: Abdus-Saboor, Ishmail John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.