NIH-funded research NIH-funded research

Exploring non-drug treatments for safely reducing opioid use in chronic pain patients

Official title: Role of Non-pharmacological Pain Treatments in Safe and Effective Opioid Tapering in Chronic Pain

Funded at VA Connecticut Healthcare System · NIH-11091437 · Data updated 2026-11-12

This study is looking at how different non-drug treatments can help people safely reduce their long-term use of opioids for chronic pain, especially during challenging times like the COVID-19 pandemic, so they can find better ways to manage their pain without relying on medication.

More Chronic Pain research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionVA Connecticut Healthcare System
NIH-funded
Lab location1 site (West Haven, United States)
Project startMay 1, 2022
Project endApril 30, 2026
Funding year2025
NIH project number5I01HX003412-04
Project IDNIH-11091437 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are veterans experiencing chronic pain who are currently on long-term opioid therapy.

Less likely to help

Patients who are not on long-term opioid therapy or do not have chronic pain may not benefit from this research.

What this research studies

This research investigates how non-pharmacological treatments can help patients safely taper off long-term opioid therapy for chronic pain. It focuses on evaluating the effectiveness of complementary and integrative health services in reducing opioid use while minimizing risks associated with tapering. The study will analyze patient outcomes during significant periods, including the implementation of a new health care system and the COVID-19 pandemic. By collaborating with various healthcare services, the research aims to develop better clinical guidelines for managing opioid tapering.

Why it matters

Potential benefit: If successful, this research could lead to safer and more effective strategies for managing chronic pain without relying on opioids.

How similar studies have gone: Previous research has shown promise in using non-pharmacological approaches for pain management, indicating potential for success in this area.

Where this research is happening

  • VA Connecticut Healthcare System
    West Haven, United States
    Active

Researchers

  • Principal investigator: Black, Anne C. — VA Connecticut Healthcare System
  • Study coordinator: Black, Anne C.

Related research

Other NIH-funded projects on the same topics.

  • Motor cortex tricks to ease chronic pain

    A study in rodents and people tests whether non-invasive brain stimulation of the motor cortex can reduce chronic pain and how best to target it.

    NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11621209

  • Human pain center study to map normal and migraine-trigeminal neurons

    A large NIH-funded project will map and study the human trigeminal neurons involved in migraines to understand what changes in these cells during headache conditions.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615140

  • Understanding human pain neurons to improve migraine care

    Researchers are studying human pain-sensing neurons to uncover what makes migraine start and persist, with the goal of better treatments for people who experience migraines.

    NIH research University of Pennsylvania · Philadelphia, United States · NIH-11615139

  • Whole Person Pain Algorithm to personalize chronic pain care

    A new, evidence-based model helps explain why chronic low back pain affects people differently and could guide personalized diagnosis and treatment.

    NIH research University of Florida · Gainesville, United States · NIH-11609318

  • Understanding how to use pharmacogenomic testing to guide chronic pain care

    This grant looks at how doctors who treat long‑term pain decide when and how to use genetic testing to tailor pain medicines for safer and more effective care.

    NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11602241

  • Mindfulness and Self-Hypnosis for Pain in Older Adults

    This grant tests non-drug ways like mindfulness and self-hypnosis to help people over 60 manage chronic pain.

    NIH research University of Washington · Seattle, United States · NIH-11599794

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.