Exploring new ways to use glucocorticoids to treat heart issues in diabetes
Official title: Harnessing novel glucocorticoid biology to treat diabetic cardiomyopathy
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-10894063 · Data updated 2026-11-12
This study is looking at how a type of steroid hormone called glucocorticoids can help improve heart function for people with diabetic cardiomyopathy, a heart issue that can happen with type-2 diabetes, by figuring out the best times to give this treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $401,250 |
| NIH project number | 5R01HL166356-02 |
| Project ID | NIH-10894063 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with type-2 diabetes who are experiencing heart-related complications.
✕Less likely to help
Patients without diabetes or those who do not have heart complications related to diabetes may not benefit from this research.
What this research studies
This research investigates how glucocorticoids, a type of steroid hormone, can be used to improve heart function in patients with diabetic cardiomyopathy, a common complication of type-2 diabetes. The study focuses on understanding the role of glucocorticoid receptors in heart cells and how their activity is influenced by the body's circadian rhythms. By examining the timing and frequency of glucocorticoid administration, the researchers aim to identify optimal treatment strategies that could enhance heart metabolism and function. The approach includes both laboratory studies and preliminary clinical trials to assess safety and effectiveness in humans.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for heart problems associated with diabetes, potentially enhancing patients' quality of life.
How similar studies have gone: Previous research has shown promising results with similar approaches, particularly in the context of circadian timing and glucocorticoid administration.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Quattrocelli, Mattia — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Quattrocelli, Mattia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.