Exploring new ways to understand heart rhythm control
Defining new pathways for cardiac automaticity
['FUNDING_OTHER'] · OHIO STATE UNIVERSITY · NIH-10653868
This study is looking at how certain genes, especially the ankyrin-B gene, affect heart rhythm problems like atrial fibrillation, with the goal of finding new ways to improve treatments for these conditions.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10653868 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic and molecular mechanisms that contribute to heart rhythm disorders, particularly focusing on the ankyrin-B gene and its variants. By examining how these genetic factors influence heart rate and rhythm through the autonomic nervous system, the study aims to uncover new pathways that could lead to better treatments for conditions like atrial fibrillation and other arrhythmias. The approach combines clinical data with molecular biology to provide a comprehensive understanding of cardiac automaticity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with known genetic variants in the ankyrin-B gene or those experiencing symptoms of cardiac arrhythmias.
Not a fit: Patients without any history of heart rhythm disorders or genetic predispositions related to the ankyrin-B gene may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients suffering from serious heart rhythm disorders.
How similar studies have performed: Previous research has shown promising results in understanding cardiac arrhythmias through genetic studies, indicating that this approach has potential for success.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: EL REFAEY, MONA — OHIO STATE UNIVERSITY
- Study coordinator: EL REFAEY, MONA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiovascular Diseases, cardiovascular disorder