Exploring new ways to influence how proteins fold and assemble in the body
Official title: Supramolecular Strategies to Modulate Biomolecular Folding and Assembly
Funded at University of Rochester · NIH-10941034 · Data updated 2026-11-12
This study is exploring how to help proteins in our bodies fold and work properly, which could lead to better treatments for conditions like Alzheimer's disease, where proteins often misfold.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $385,000 |
| NIH project number | 1R35GM155222-01 |
| Project ID | NIH-10941034 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for or diagnosed with Alzheimer's disease or other conditions related to protein misfolding.
✕Less likely to help
Patients with conditions unrelated to protein folding or assembly may not benefit from this research.
What this research studies
This research investigates how proteins and other biomolecules can be guided to adopt specific structures and functions through the use of synthetic supramolecular complexes. By mimicking natural processes and using noncovalent interactions, the study aims to develop new therapeutic strategies that can better influence protein folding and assembly. Patients may benefit from advancements in understanding and treating conditions like Alzheimer's disease, where protein misfolding plays a critical role. The approach combines chemistry and biology to create dynamic structures that can interact with biological systems more effectively than traditional small molecules.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for diseases associated with protein misfolding, such as Alzheimer's.
How similar studies have gone: While the approach of using supramolecular chemistry is innovative, similar strategies have shown promise in other areas of biomedical research.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Partridge, Benjamin Edward — University of Rochester
- Study coordinator: Partridge, Benjamin Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.