Exploring new ways to improve heart repair after injury
Identifying novel pathways targeting endothelial-to-mesenchymal transition during heart failure
This study is looking at how a process that helps heart cells change can improve healing after a heart attack, and it’s exploring a new tiny molecule that might help make heart recovery better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10438710 on NIH RePORTER |
What this research studies
This research investigates how a specific process called endothelial-to-mesenchymal transition (EndoMT) affects heart repair following a heart attack. The team aims to understand the role of a newly discovered microRNA in regulating EndoMT and how this knowledge can lead to better treatments for heart failure. By enhancing blood supply and stimulating the growth of new heart cells, the research seeks to improve recovery outcomes for patients with myocardial infarction. The approach combines laboratory studies with potential clinical applications to translate findings into real-world therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a myocardial infarction or have heart failure.
Not a fit: Patients with non-cardiac conditions or those who have not experienced heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve heart recovery and function after a heart attack.
How similar studies have performed: Previous research has shown promise in understanding EndoMT's role in heart failure, but this specific approach is relatively novel and aims to uncover new therapeutic pathways.
Where this research is happening
Indianapolis, United States
- Indiana University Indianapolis — Indianapolis, United States (Active)
Researchers
- Principal investigator: Kim, Il-Man — Indiana University Indianapolis
- Study coordinator: Kim, Il-Man
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.