Exploring new ways to create and test protein variants for gene regulation
Methods to Rapidly Explore Combinatorial Diversity and their Application to CRISPR-Cas9 Systems
This study is testing a new way to quickly create and study many different protein versions to improve tools that help control gene activity, which could lead to better treatments for neurodegenerative diseases like Alzheimer's or Parkinson's, ultimately helping patients manage their conditions more effectively.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10935530 on NIH RePORTER |
What this research studies
This research focuses on developing a novel method called BArcoded Combinatorial Engineering and Screening (BaCES) to rapidly create and evaluate thousands of protein variants. By using this innovative approach, researchers aim to enhance Cas9-based transcriptional regulators, which are tools that can modify gene expression. The goal is to better understand how neurons respond to neurodegenerative challenges, potentially leading to new treatments. Patients may benefit from advancements in gene therapy and neurodegenerative disease management as a result of this work.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurodegenerative conditions or those interested in gene therapy advancements.
Not a fit: Patients with conditions unrelated to neurodegenerative diseases or those not involved in gene therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to transformative technologies for gene regulation that improve treatment options for neurodegenerative diseases.
How similar studies have performed: Other research has shown success with combinatorial engineering approaches, indicating potential for breakthroughs in gene regulation.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Chavez, Alejandro — University of California, San Diego
- Study coordinator: Chavez, Alejandro
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.