Exploring new ways eicosanoids are made and used in the body
Novel pathways in eicosanoid biosynthesis and metabolism
['FUNDING_OTHER'] · VANDERBILT UNIVERSITY · NIH-10928704
This study is looking at how certain enzymes change a fatty acid in your body into important substances that help control various functions, and it's especially for people who use non-steroidal anti-inflammatory drugs (NSAIDs) to see if we can find new ways to tell how well these medications are working for you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY (nih funded) |
| Locations | 1 site (Nashville, UNITED STATES) |
| Trial ID | NIH-10928704 on ClinicalTrials.gov |
What this research studies
This research investigates how certain enzymes transform arachidonic acid into eicosanoids, which are important lipid mediators that help regulate various cellular processes in both health and disease. The project focuses on two main areas: the interaction between different biosynthetic pathways and the identification of new eicosanoid transformations that could impact the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs). By understanding these processes better, the research aims to uncover potential biomarkers in blood and urine that could indicate how well patients respond to these medications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are using or may benefit from non-steroidal anti-inflammatory drugs for inflammatory conditions.
Not a fit: Patients who do not use NSAIDs or have conditions unrelated to inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for conditions that involve inflammation and pain, enhancing the effectiveness of NSAIDs.
How similar studies have performed: Previous research has shown promising results in understanding eicosanoid pathways, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Nashville, UNITED STATES
- VANDERBILT UNIVERSITY — Nashville, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHNEIDER, CLAUS — VANDERBILT UNIVERSITY
- Study coordinator: SCHNEIDER, CLAUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.