Exploring new treatments to help nerves heal after spinal cord injuries
Identifying novel regenerative treatments for CNS injury in adult mammals
This study is looking at how certain proteins and genes can help nerves heal better after a spinal cord injury, with the hope of finding new treatments that could help people regain lost functions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10894127 on NIH RePORTER |
What this research studies
This research investigates how targeting specific proteins and genes can enhance the regeneration of axons, which are crucial for nerve function, after spinal cord injuries. The study focuses on the transcription factor ZNF362 and non-muscle myosin proteins, which play significant roles in the growth capacity of neurons. By understanding how these elements interact in the environment following an injury, the research aims to develop effective therapies that could restore lost functions in patients. The approach combines genetic targeting with innovative therapeutic strategies to potentially improve recovery outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have experienced spinal cord injuries.
Not a fit: Patients with spinal cord injuries who are under 21 years old or those with injuries that are not amenable to regenerative treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and quality of life for individuals with spinal cord injuries.
How similar studies have performed: While there have been various studies targeting neuronal growth factors, this specific approach focusing on ZNF362 and cytoskeletal proteins is relatively novel and has not been extensively tested in clinical settings.
Where this research is happening
Philadelphia, United States
- Temple Univ of the Commonwealth — Philadelphia, United States (Active)
Researchers
- Principal investigator: Li, Shuxin — Temple Univ of the Commonwealth
- Study coordinator: Li, Shuxin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.