Exploring new treatments for opioid use disorder using specific receptor blockers
Evaluation of the therapeutic potential of exclusive antagonists of extrasynaptic NMDA receptors for the treatment of opioid use disorder
This study is looking at how a medication called memantine might help people with opioid addiction by reducing withdrawal symptoms and the chance of relapse, offering a new treatment option for those struggling with this condition.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Neurano Bioscience NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-11078347 on NIH RePORTER |
What this research studies
This research investigates the potential of exclusive antagonists of extrasynaptic NMDA receptors to treat opioid use disorder. By focusing on a specific drug, memantine, which has shown promise in reducing withdrawal symptoms and relapse risk, the study aims to develop a more effective therapy for individuals struggling with opioid addiction. The approach involves understanding how these receptors contribute to addiction and testing the drug's efficacy in a controlled setting. Patients may benefit from a new treatment option that targets the underlying mechanisms of opioid dependence.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with opioid use disorder who are seeking new treatment options.
Not a fit: Patients who are not struggling with opioid use disorder or those who have not responded to previous treatments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment option for individuals with opioid use disorder.
How similar studies have performed: Previous research has shown promising results with NMDA receptor antagonists in addiction treatment, indicating potential for success in this approach.
Where this research is happening
La Jolla, UNITED STATES
- Neurano Bioscience — La Jolla, United States (Active)
Researchers
- Principal investigator: Molokanova, Elena — Neurano Bioscience
- Study coordinator: Molokanova, Elena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.