Exploring new treatments for liver disease caused by alcohol consumption
Official title: Inflammation Resolving Lipid Mediators: Novel Therapy for Alcohol AssociatedLiver Disease
Funded at Louisville VA Medical Medical Center · NIH-10862575 · Data updated 2026-11-12
This study is looking at how certain healthy fats, like omega-3s, might help people with alcohol-related liver disease by reducing inflammation and helping the liver heal.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisville VA Medical Medical Center NIH-funded |
| Lab location | 1 site (Louisville, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01CX002219-06 |
| Project ID | NIH-10862575 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with alcohol-associated liver disease, particularly those experiencing inflammation and liver injury.
✕Less likely to help
Patients with liver disease not related to alcohol consumption may not benefit from this research.
What this research studies
This research investigates the role of specific dietary fats, particularly omega-3 polyunsaturated fatty acids (PUFAs), in treating alcohol-associated liver disease (ALD). The study focuses on how these fats can produce pro-resolving mediators that help reduce inflammation and promote liver repair. By understanding the mechanisms behind these effects, the research aims to identify potential new therapies that could improve liver health in individuals affected by ALD. The approach includes examining the signaling pathways involved in inflammation resolution and liver injury repair.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic options for patients suffering from alcohol-associated liver disease.
How similar studies have gone: Previous research has shown promising results with omega-3 fatty acids in reducing inflammation and promoting liver health, suggesting potential for success in this novel approach.
Where this research is happening
-
Louisville VA Medical Medical Center
Louisville, United States Active
Researchers
- Principal investigator: Mcclain, Craig J. — Louisville VA Medical Medical Center
- Study coordinator: Mcclain, Craig J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.