Exploring new treatments for breathing problems related to obesity
Official title: Cultivating novel treatments for obesity-related respiratory disease by uncovering neuronal etiology
Funded at Marquette University · NIH-10730653 · Data updated 2026-11-12
This study is looking at how the brain affects breathing problems in people with obesity, especially those with Obesity Hypoventilation Syndrome, to find new ways to help them breathe better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Marquette University NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 5, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $456,882 |
| NIH project number | 1R15HL170276-01 |
| Project ID | NIH-10730653 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Obesity Hypoventilation Syndrome or those experiencing significant breathing difficulties related to obesity.
✕Less likely to help
Patients who do not have obesity or related respiratory issues may not benefit from this research.
What this research studies
This research investigates the underlying brain mechanisms that contribute to breathing difficulties in individuals with obesity, specifically focusing on a condition known as Obesity Hypoventilation Syndrome (OHS). By examining how certain brain regions interact and affect breathing sensitivity, the study aims to uncover new treatment strategies that could improve patient outcomes. The researchers will use advanced techniques, including genetic models and brain imaging, to map the neuronal circuits involved in this condition. Ultimately, the goal is to develop effective pharmaceutical treatments that address the root causes of respiratory issues in obese patients.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve breathing and overall health for patients suffering from obesity-related respiratory diseases.
How similar studies have gone: While the approach of targeting brain mechanisms in obesity-related respiratory issues is relatively novel, similar research has shown promise in understanding the neurological aspects of other obesity-related conditions.
Where this research is happening
-
Marquette University
Milwaukee, United States Active
Researchers
- Principal investigator: Arble, Deanna Marie — Marquette University
- Study coordinator: Arble, Deanna Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.