Exploring new treatments for aggressive brain tumors
Leveraging reactive metabolite generation in brain tumors
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11048870
This study is looking for new ways to treat aggressive brain tumors in adults by figuring out how certain substances in the body help these tumors grow, so they can find better treatments that work alongside current options.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11048870 on ClinicalTrials.gov |
What this research studies
This research focuses on developing innovative therapies for adult gliomas, particularly those with specific mutations that make them more aggressive. The approach involves understanding how certain metabolites affect tumor growth and how they can be targeted to improve treatment outcomes. By using patient-derived models and biopsies, the researchers aim to identify ways to inhibit tumor growth by disrupting the cancer cells' ability to detoxify harmful substances. The study combines novel drug treatments with existing therapies to enhance their effectiveness.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with gliomas that have mutations in isocitrate dehydrogenase 1 or 2 (IDHm).
Not a fit: Patients with gliomas that do not have IDHm mutations or those with other types of brain tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for patients with aggressive brain tumors, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in gliomas, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VISWANATH, PAVITHRA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: VISWANATH, PAVITHRA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.