Exploring new T cell targets in type 1 diabetes
The "dark immunopeptidome" as a source of CD8 T cell epitopes in type 1 diabetes
This study is looking at how specific immune cells in the body recognize certain pieces of insulin that might play a role in type 1 diabetes, with the hope of finding new ways to understand and treat the condition for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10771213 on NIH RePORTER |
What this research studies
This research investigates how certain T cells recognize unique insulin peptides that may contribute to type 1 diabetes. By analyzing the immunopeptidome of human pancreatic islets, the study aims to identify unconventional insulin peptides that could be targeted by cytotoxic T cells. The approach involves advanced techniques like mass spectrometry to uncover these peptide interactions, which could lead to new insights into the immune response in type 1 diabetes. Patients may benefit from a better understanding of their condition and potential new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 1 diabetes who may have specific HLA types.
Not a fit: Patients with type 2 diabetes or those without the relevant HLA types may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that improve the management of type 1 diabetes.
How similar studies have performed: Previous research has shown success in identifying T cell targets in other autoimmune conditions, suggesting potential for this approach in type 1 diabetes.
Where this research is happening
Bronx, United States
- Albert Einstein College of Medicine — Bronx, United States (Active)
Researchers
- Principal investigator: Dilorenzo, Teresa P — Albert Einstein College of Medicine
- Study coordinator: Dilorenzo, Teresa P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.