Exploring new signaling molecules for cardiovascular health
Official title: Nitro-nitrate fatty acid derivatives as novel cGMP-dependent and cGMP-independent signaling mediators
Funded at University of Pittsburgh at Pittsburgh · NIH-11001144 · Data updated 2026-11-12
This study is looking at how certain compounds from our diet might help improve heart health by affecting inflammation and gene activity, with the hope of finding new treatment options for people with heart conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $540,936 |
| NIH project number | 5R01HL162787-03 |
| Project ID | NIH-11001144 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for cardiovascular diseases or those currently managing such conditions.
✕Less likely to help
Patients with non-cardiovascular related health issues may not receive any benefit from this research.
What this research studies
This research investigates the potential of nitro-nitrate fatty acid derivatives as new signaling mediators that could improve cardiovascular health. It focuses on how these compounds, derived from dietary sources, can influence biological processes related to cardiovascular diseases. By examining their effects on gene expression and inflammation, the study aims to identify alternative therapies that could enhance treatment outcomes for patients with cardiovascular conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve cardiovascular health and reduce the incidence of related diseases.
How similar studies have gone: Previous research has shown promising results with dietary interventions in cardiovascular health, suggesting that this approach may yield beneficial outcomes.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Fazzari, Marco — University of Pittsburgh at Pittsburgh
- Study coordinator: Fazzari, Marco
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.