Exploring new roles of telomeres in cell division and genome stability
Defining the mechanisms and consequences of noncanonical telomere functions
['FUNDING_R01'] · UNIVERSITY OF COLORADO DENVER · NIH-11051778
This study is exploring how telomeres, which are the protective caps on our chromosomes, help cells divide properly and keep our genes stable, with the hope that understanding this could lead to better cancer treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF COLORADO DENVER (nih funded) |
| Locations | 1 site (Aurora, UNITED STATES) |
| Trial ID | NIH-11051778 on ClinicalTrials.gov |
What this research studies
This research investigates the newly discovered functions of telomeres beyond their traditional role of protecting chromosome ends. It focuses on how telomeres interact with cellular structures during cell division, particularly in meiosis, to ensure proper nuclear envelope breakdown and centromere assembly. By conducting a series of experiments, the research aims to uncover the mechanisms by which telomeres contribute to genome stability and prevent cancer development. Patients may benefit from insights gained into how telomere functions can influence cancer cell behavior and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with cancers associated with telomere instability or those at high risk for such conditions.
Not a fit: Patients with non-cancerous conditions unrelated to telomere function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cancers linked to telomere dysfunction.
How similar studies have performed: While the traditional roles of telomeres are well-established, the exploration of their noncanonical functions is relatively novel, suggesting that this research could pave the way for new discoveries.
Where this research is happening
Aurora, UNITED STATES
- UNIVERSITY OF COLORADO DENVER — Aurora, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: COOPER, JULIA PROMISEL — UNIVERSITY OF COLORADO DENVER
- Study coordinator: COOPER, JULIA PROMISEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: cancer cell, cancer/testis antigen 35, Cancers