Exploring new ring-shaped molecules to influence protein interactions
Disrupting Protein-Protein Interactions with Self-Assembling Macrocycles
['FUNDING_R15'] · TEXAS CHRISTIAN UNIVERSITY · NIH-10796097
This study is exploring new ring-shaped molecules that could help create better drugs for diseases like breast cancer by changing how proteins interact with each other.
Quick facts
| Phase | ['FUNDING_R15'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEXAS CHRISTIAN UNIVERSITY (nih funded) |
| Locations | 1 site (FORT WORTH, UNITED STATES) |
| Trial ID | NIH-10796097 on ClinicalTrials.gov |
What this research studies
This research investigates a novel class of ring-shaped molecules, known as macrocycles, which have the potential to modulate interactions between proteins. By utilizing dynamic covalent chemistry, the researchers aim to create these macrocyclic compounds in a way that allows for precise control over their structure and function. This could lead to the development of new drugs that target specific protein interactions, which is crucial for treating various diseases, including breast cancer. The project focuses on understanding how changes in the molecular structure can affect the efficacy of these compounds in drug design.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with breast cancer who may benefit from new therapeutic strategies targeting protein interactions.
Not a fit: Patients with conditions unrelated to protein interactions or those who are not diagnosed with cancer may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of innovative therapies for diseases like breast cancer by targeting protein interactions more effectively.
How similar studies have performed: While the approach of using macrocyclic molecules to influence protein interactions is relatively novel, there is growing interest and investment in this area, indicating potential for success based on preliminary findings in related research.
Where this research is happening
FORT WORTH, UNITED STATES
- TEXAS CHRISTIAN UNIVERSITY — FORT WORTH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIMANEK, ERIC E — TEXAS CHRISTIAN UNIVERSITY
- Study coordinator: SIMANEK, ERIC E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.