Exploring new molecular mechanisms in Alzheimer's disease
Systems Approaches to Novel Molecular Mechanism in Alzheimer's Disease
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-10815452
This study is looking at how certain proteins, called Midkine and Netrin, affect the progression of Alzheimer's disease and their relationship with a harmful protein known as amyloid beta, with the hope of finding new ways to help people with Alzheimer's in the future.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10815452 on ClinicalTrials.gov |
What this research studies
This research investigates the role of specific proteins, Midkine and Netrin, in the progression of Alzheimer's disease and how they interact with amyloid beta, a key protein involved in the disease. By utilizing advanced proteomic techniques, the study aims to uncover the molecular pathways that contribute to neuron damage in Alzheimer's patients. The findings could lead to a better understanding of the disease and potentially identify new therapeutic targets. Patients may benefit from insights that could inform future treatments and interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those experiencing age-related cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function and slow the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting amyloid-related mechanisms in Alzheimer's, but the specific approach of this study is novel and aims to expand understanding beyond amyloid pathology.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YU, GANG — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: YU, GANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's Disease Pathway