Exploring new methods to study human kinases and their role in cancer treatment
Official title: New Proteomics Approaches to Study the Full Human Kinome, Inhibitor Resistance, and Kinase Degraders
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10722799 · Data updated 2026-11-12
This study is looking at special proteins that play a big role in cancer to find better treatments, and it’s for anyone affected by cancer who hopes for new options to fight their disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | July 23, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $211,918 |
| NIH project number | 1K22CA282268-01 |
| Project ID | NIH-10722799 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with various types of cancer, particularly those whose treatment options are limited due to kinase inhibitor resistance.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancers are already effectively treated by existing therapies may not benefit from this research.
What this research studies
This research focuses on understanding protein kinases, which are crucial enzymes involved in many cancers. The project aims to develop advanced proteomics technologies to measure kinase levels in cancer samples, investigate how some kinases resist treatment, and discover new compounds that can degrade these kinases. By creating a high-throughput screening platform, the research will enable the identification of potential new therapies targeting the kinome, which is largely unexplored. Patients may benefit from improved cancer treatments based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to the development of new cancer therapies that target previously understudied kinases.
How similar studies have gone: Other research has shown promise in targeting kinases for cancer treatment, but this approach aims to explore largely unstudied kinases, making it a novel endeavor.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Yu, Qing — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Yu, Qing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.