Exploring new human genes that produce different proteins from existing ones
Translation of overprinted non-canonical open reading frames from alternative transcript variants
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10943268
This study is looking at a new type of genes in humans that can create special proteins, and it's for anyone interested in understanding how our genes work and how they might affect our health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10943268 on ClinicalTrials.gov |
What this research studies
This research investigates a newly discovered class of human genes known as internal open reading frames (iORFs), which can produce distinct proteins that differ from those encoded by the main gene. By using advanced long-read sequencing technologies, the researchers aim to identify and validate these iORFs in human cells. The study will also explore the functional roles of these microproteins and how they relate to the canonical proteins they overlap. This could provide insights into the complexity of gene expression and protein function in human biology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions or diseases that may be influenced by the expression of alternative protein products.
Not a fit: Patients with conditions unrelated to genetic variations or those not expressing iORFs may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of gene function and the development of new therapeutic strategies for diseases linked to these novel proteins.
How similar studies have performed: While the exploration of iORFs is a relatively novel area, previous research on overlapping genes in viral genomes has shown promising results, suggesting potential for success in human studies.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SLAVOFF, SARAH ANN — YALE UNIVERSITY
- Study coordinator: SLAVOFF, SARAH ANN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.