Exploring new genetic interactions in Acute Myeloid Leukemia
Investigating novel synthetic lethal epigenetic interactions in Acute Myeloid Leukemia
This study is looking at how certain genes work together in Acute Myeloid Leukemia (AML) to find new ways to treat this blood cancer, so that patients can have better options for their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11003311 on NIH RePORTER |
What this research studies
This research investigates the complex genetic interactions that contribute to Acute Myeloid Leukemia (AML), a type of blood cancer. Using advanced CRISPR technology, the team aims to identify how certain epigenetic regulators work together to influence the disease. By understanding these interactions, the researchers hope to uncover new therapeutic targets that could lead to more effective treatments for AML patients. The study focuses on specific genetic combinations that may reveal vulnerabilities in AML cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Acute Myeloid Leukemia who may benefit from novel therapeutic approaches.
Not a fit: Patients with other types of leukemia or those who do not have a diagnosis of Acute Myeloid Leukemia may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective treatments for patients with Acute Myeloid Leukemia.
How similar studies have performed: Other research has shown promise in targeting epigenetic interactions in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Shi, Junwei — University of Pennsylvania
- Study coordinator: Shi, Junwei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.