Exploring new drug possibilities using unique molecular structures
Official title: Harnessing Atropisomerism in beta-Carbolines for the Discovery of New Reactions and Small Molecule Probes
Funded at Providence College · NIH-10730343 · Data updated 2026-11-12
This study is looking at a special kind of small molecule called β-carbolines to see if they can be turned into new and better medicines for different diseases, with a team of undergraduate researchers working to make them more stable and effective.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Providence College NIH-funded |
| Lab location | 1 site (Providence, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $407,325 |
| NIH project number | 1R15GM151647-01 |
| Project ID | NIH-10730343 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from conditions that could benefit from new therapeutic agents targeting acetylcholine-related pathways.
✕Less likely to help
Patients with conditions unrelated to acetylcholine or those who do not respond to traditional drug therapies may not benefit from this research.
What this research studies
This research investigates the potential of a specific type of small molecule, known as β-carbolines, which exhibit a unique property called atropisomerism. By studying these molecules, the research aims to discover new therapeutic agents that could be effective in treating various diseases. The team, composed of undergraduate researchers, will explore how these molecules can be manipulated to enhance their stability and effectiveness as drugs. The focus is on understanding the behavior of these molecules to develop innovative strategies for drug discovery.
Why it matters
Potential benefit: If successful, this research could lead to the development of new medications that are more effective in treating diseases.
How similar studies have gone: Previous research has shown promise in utilizing atropisomerism in drug development, indicating that this approach could yield significant advancements.
Where this research is happening
-
Providence College
Providence, United States Active
Researchers
- Principal investigator: Mulcahy, Seann Patrick — Providence College
- Study coordinator: Mulcahy, Seann Patrick
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.