Exploring new drug combinations for Alzheimer's disease and related dementias
Finding combinatorial drug repositioning therapy for Alzheimer's disease and related dementias
This study is exploring new ways to treat Alzheimer's and related dementias by combining existing medications to find better options for patients who haven't had success with current treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Sci Ctr Houston NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10809653 on NIH RePORTER |
What this research studies
This research investigates the potential of combinatorial drug therapy to treat Alzheimer's disease and related dementias by utilizing big data and advanced informatics models. The approach aims to identify existing drugs that can be repositioned and combined to create more effective treatments, particularly for patients who have not responded well to current therapies. By integrating various biomedical data sources and conducting biological experiments, the research seeks to overcome challenges such as drug resistance and target multiple disease pathways. If successful, this innovative methodology could lead to safer and more effective treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias, particularly those who have not responded to existing treatments.
Not a fit: Patients with early-stage cognitive impairment or those without a formal diagnosis of Alzheimer's disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide patients with more effective treatment options for Alzheimer's disease and related dementias.
How similar studies have performed: While combinatorial drug therapy has not been extensively studied in this context, there is growing interest and preliminary evidence suggesting that such approaches could be promising for treating complex diseases like Alzheimer's.
Where this research is happening
Houston, United States
- University of Texas Hlth Sci Ctr Houston — Houston, United States (Active)
Researchers
- Principal investigator: Jiang, Xiaoqian — University of Texas Hlth Sci Ctr Houston
- Study coordinator: Jiang, Xiaoqian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.