Exploring new CRISPR tools to understand how bacteria resist antibiotics
New CRISPR tools for systematic interrogation of genetic and transcriptional determinants of antibiotic sensitivity in bacteria
This study is looking at how bacteria become resistant to antibiotics and aims to find ways to make them more sensitive to treatment, which could help improve care for infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10909384 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex mechanisms that allow bacteria to resist antibiotics, which is a significant public health threat. By using advanced CRISPR technology, the project aims to systematically investigate both genetic and non-genetic factors that influence bacterial sensitivity to antibiotics. The approach involves developing a novel genome-wide CRISPR-interference screening method to identify how certain genes can make bacteria more susceptible to antibiotic treatment. This could lead to new strategies for overcoming antibiotic resistance and improving treatment outcomes for infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from bacterial infections that are resistant to standard antibiotic treatments.
Not a fit: Patients with infections caused by bacteria that are already effectively treated with current antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antimicrobial strategies that enhance the effectiveness of existing antibiotics against resistant bacterial infections.
How similar studies have performed: Previous research using CRISPR technology has shown promise in understanding genetic factors in antibiotic resistance, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Jiang, Wenyan — Icahn School of Medicine at Mount Sinai
- Study coordinator: Jiang, Wenyan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.