Exploring new compounds to fight bacterial infections and other diseases
Official title: Indole Alkaloids and Halogenated Phenazines: Platforms for Discovery
Funded at University of Georgia · NIH-11061094 · Data updated 2026-11-12
This study is exploring new types of medicines made from natural compounds to find better treatments for tough bacterial infections and cancer, especially for patients who have infections that don’t respond to regular antibiotics.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Georgia NIH-funded |
| Lab location | 1 site (Athens, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $331,600 |
| NIH project number | 5R35GM153272-03 |
| Project ID | NIH-11061094 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from bacterial infections, particularly those caused by antibiotic-resistant strains.
✕Less likely to help
Patients with non-bacterial infections or those not affected by antibiotic resistance may not benefit from this research.
What this research studies
This research focuses on developing small molecule probes derived from indole alkaloids and halogenated phenazines to investigate and treat various human diseases, including bacterial infections and cancer. The team will modify these compounds to enhance their biological functions and study their effects on disease mechanisms. By creating new chemical structures, they aim to identify effective treatments for persistent bacterial infections, particularly those associated with biofilms. Patients may benefit from the discovery of novel antibacterial agents that can overcome antibiotic resistance.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat bacterial infections, especially those resistant to current treatments.
How similar studies have gone: Previous research has shown promise in using small molecule probes for drug discovery, indicating potential success for this novel approach.
Where this research is happening
-
University of Georgia
Athens, United States Active
Researchers
- Principal investigator: Huigens, Robert William — University of Georgia
- Study coordinator: Huigens, Robert William
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.