Exploring new antibiotics to combat drug-resistant bacteria
Official title: Physical Biology and Deep Learning for Antibiotic Resistance and Discovery
Funded at Broad Institute, INC. · NIH-11003271 · Data updated 2026-11-12
This study is looking at how bacteria die when they come into contact with antibiotics to find new treatments that can help fight infections that don't respond to current medicines, especially for patients dealing with tough antibiotic-resistant infections.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $125,706 |
| NIH project number | 5K25AI168451-04 |
| Project ID | NIH-11003271 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antibiotic-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by bacterial pathogens or those who do not have antibiotic-resistant infections may not benefit from this research.
What this research studies
This research investigates how bacteria die when exposed to antibiotics and aims to discover new antibiotics by analyzing the physical changes in bacterial cells. By studying the cellular pathways involved in antibiotic action, the project seeks to develop innovative methods for antibiotic discovery using a vast library of chemical compounds. Patients may benefit from new treatments that can effectively combat antibiotic-resistant infections, which are becoming increasingly common. The research employs advanced techniques like microfluidics and deep learning to enhance the discovery process.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antibiotics that effectively treat infections caused by drug-resistant bacteria.
How similar studies have gone: Other research has shown promise in using similar approaches to discover new antibiotics, indicating potential for success in this novel investigation.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Wong, Felix — Broad Institute, INC.
- Study coordinator: Wong, Felix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.