Exploring natural compounds to prevent colorectal cancer
Official title: Discovery and Development of Natural Products for Interception of CRC
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-11088894 · Data updated 2026-11-12
This study is looking for natural products that can help stop the growth of colorectal cancer by targeting specific enzymes that are active in early cancer stages, aiming to find safe options for prevention.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | May 14, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $303,875 |
| NIH project number | 5UG3CA290310-02 |
| Project ID | NIH-11088894 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at high risk for colorectal cancer, such as those with a family history or previous adenomas.
✕Less likely to help
Patients with advanced colorectal cancer or those who have already undergone extensive treatment may not benefit from this research.
What this research studies
This research focuses on identifying and developing natural products that can effectively target specific pathways involved in the progression of colorectal cancer (CRC). By utilizing a vast library of pre-fractionated natural compounds, the study aims to screen for bioactive fractions that inhibit key enzymes associated with tumor growth. The targeted enzymes, mPGES-1, 5-LOX, and ODC, are known to be over-expressed in early cancer lesions, making them critical for intervention. The goal is to find natural agents that can selectively inhibit these targets without causing toxicity, potentially leading to safer cancer prevention strategies.
Why it matters
Potential benefit: If successful, this research could lead to new, effective natural therapies for preventing colorectal cancer.
How similar studies have gone: Previous research has shown promise in using natural products for cancer treatment, indicating potential for success in this novel approach.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Rao, Chinthalapally V. — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Rao, Chinthalapally V.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.