Exploring lung cancer genetics in patients of African ancestry
Official title: Understanding lung cancer genomics in patients of African ancestry
Funded at Sloan-Kettering Inst Can Research · NIH-10981834 · Data updated 2026-11-12
This study is looking into the genetic differences in lung cancer for people of African ancestry to find out why they often don't get the same advanced treatments as white patients, with the hope of improving care and outcomes for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $730,398 |
| NIH project number | 1R01CA286469-01A1 |
| Project ID | NIH-10981834 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American individuals diagnosed with lung cancer.
✕Less likely to help
Patients of non-African ancestry may not benefit directly from the findings of this research.
What this research studies
This research investigates the unique genetic factors associated with lung cancer in individuals of African ancestry. It aims to understand why these patients are less likely to receive advanced genomic testing and targeted therapies compared to their white counterparts. By analyzing real-world data, the study will identify specific genetic alterations and their frequencies in lung cancer among African American patients. The goal is to uncover disparities in treatment and improve outcomes for this population by tailoring therapies based on their genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for lung cancer patients of African ancestry.
How similar studies have gone: Previous research has shown that understanding genetic differences in cancer can lead to significant advancements in treatment, suggesting this approach has potential for success.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Zhang, Jian — Sloan-Kettering Inst Can Research
- Study coordinator: Zhang, Jian
Related research
Other NIH-funded projects on the same topics.
-
Blood-based markers to identify lung cancer risk in never-smokers
A researchers team at NYU School of Medicine is testing blood tests that might flag higher lung cancer risk in people who have never smoked, helping decide who might need screening.
-
Integrative Analysis of Lung Cancer Risk and Its Causes
A large, multi-part study at the University of New Mexico is exploring why lung cancer happens and how to better prevent and detect it.
-
Integrative Analysis of Lung Cancer Risk and Causes
A large NIH project is exploring how tobacco use, behavior, biology, and screening practices influence lung cancer risk and outcomes to help prevent and detect it earlier.
-
Digital health strategies to expand lung cancer screening in safety-net clinics
A funded project aims to help low-resource clinics increase the use of lung cancer screening for patients who smoke or are at risk.
-
Proteomics-guided matching of lung cancer tumors to preclinical models
This grant aims to improve how we match a patient’s lung cancer tumor to the right preclinical models using protein data.
-
Optimizing lung cancer care with smart tools for prevention, early detection, treatment, and survivorship
A U01 grant using AI and biomarkers to improve lung cancer prevention, screening, treatment, and survivorship care for people at risk or living with lung cancer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.