Exploring key proteins involved in common fungal infections
Structural and functional studies of Hsp70/Hsp110 molecular chaperones
This research looks at how certain proteins in common fungal infections work, and tests a new way to stop them from causing problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Virginia Commonwealth University NIH-funded |
| Lab location | 1 site (Richmond, United States) |
| Project ID | NIH-11105936 on NIH RePORTER |
What this research studies
Fungal infections, like those caused by Candida albicans, are common and can be serious. Our bodies and these fungi have special proteins called chaperones (Hsp70s and Hsp110s) that help other proteins fold correctly to function properly. This project aims to understand how a specific chaperone, Hsp110, works in Candida albicans, especially its 'holdase activity' which prevents harmful protein clumping. Researchers have found a new substance, called 2H, that can specifically block this holdase activity in the fungus. By studying how 2H affects the fungus, we hope to learn more about how these chaperones contribute to fungal survival and infection.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this work may seek individuals with fungal infections.
Not a fit: Patients not affected by fungal infections would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new medications to treat common fungal infections in humans.
How similar studies have performed: This research explores a novel inhibitor for fungal Hsp110s, providing new insights into their role in infection.
Where this research is happening
Richmond, United States
- Virginia Commonwealth University — Richmond, United States (Active)
Researchers
- Principal investigator: Liu, Qinglian — Virginia Commonwealth University
- Study coordinator: Liu, Qinglian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.