Exploring immune system responses to infections and diseases using advanced sequencing techniques
Investigation of the landscape of immunosequencing and its clinical relevance through novel immunoinformatic approaches
This study is looking at how our immune system fights off infections and diseases by examining the different types of immune receptors, and it aims to help improve treatments and tests for patients by understanding how these immune responses work over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11054666 on NIH RePORTER |
What this research studies
This research investigates how the adaptive immune system recognizes and eliminates antigens from infections and diseases, focusing on the diversity of immune receptors like B-cell and T-cell receptors. By utilizing advanced sequencing technologies and machine learning methods, the study aims to analyze the immune repertoire over time and correlate it with clinical outcomes. Patients may benefit from improved immunotherapies and diagnostics as the research seeks to identify specific immune responses that can be targeted for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with conditions that affect the immune system, such as cancer patients or those recovering from viral infections.
Not a fit: Patients with stable, non-immune related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective immunotherapies and diagnostic tools for various diseases, including cancer and viral infections.
How similar studies have performed: Previous research has shown promise in using advanced sequencing and machine learning to analyze immune responses, indicating that this approach could yield valuable insights.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Zhang, Li — University of California, San Francisco
- Study coordinator: Zhang, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.