Exploring immune responses in Alzheimer's disease using advanced imaging techniques
Official title: Investigating whole-body innate immune activation in Alzheimer's disease using PET imaging and immune profiling
Funded at Washington University · NIH-11013366 · Data updated 2026-11-12
This study is looking at how inflammation in the body might influence Alzheimer's disease, using special imaging and tests to see how the immune system works in both lab models and people with the condition, all to help us better understand and manage Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $244,019 |
| NIH project number | 5R00AG070105-05 |
| Project ID | NIH-11013366 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at risk for developing it.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates the role of inflammation in Alzheimer's disease by using whole-body PET imaging and immune profiling. It aims to understand how peripheral inflammatory responses may affect the risk and progression of Alzheimer's. The study will involve both preclinical models and clinical assessments to evaluate immune responses in patients. By examining these immune signatures, the research seeks to improve the understanding of Alzheimer's disease and enhance clinical evaluation methods.
Why it matters
Potential benefit: If successful, this research could lead to new immunomodulatory treatments for Alzheimer's disease that target inflammation.
How similar studies have gone: Previous research has shown promising results in understanding inflammation's role in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Chaney, Aisling — Washington University
- Study coordinator: Chaney, Aisling
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.