Exploring how young blood can improve brain function in older adults
Systemic Mechanisms of Brain Rejuvenation
This study is looking at whether certain substances found in the blood of young mice can help improve brain function in older adults, with the hope of finding new ways to tackle memory and thinking problems that come with aging.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11060956 on NIH RePORTER |
What this research studies
This research investigates the potential of using factors found in young blood to enhance cognitive function in older adults. By examining how these circulating factors can rejuvenate the brain, the study aims to understand their effects on neurogenesis and cognitive decline associated with aging. The approach includes administering platelet factors derived from young or exercised mice to see if they can reverse age-related impairments in brain function. This innovative method could lead to new therapies for age-related cognitive disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing age-related cognitive decline or neurodegenerative conditions.
Not a fit: Patients with cognitive impairments not related to aging or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to groundbreaking treatments that improve cognitive function and quality of life for older adults experiencing memory decline.
How similar studies have performed: Previous studies have shown promising results using young blood and its components to rejuvenate brain function, indicating a potential for success in this novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Villeda, Saul a — University of California, San Francisco
- Study coordinator: Villeda, Saul a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.