Exploring how WNT9A and FZD9 proteins communicate and signal in cells
Understanding WNT9A/FZD9 Trafficking and Signaling
This study is looking at how certain proteins help cells talk to each other, which is important for things like growth and health, and it could help us understand more about how diseases work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10908399 on NIH RePORTER |
What this research studies
This research investigates the mechanisms of cell-to-cell communication through specific proteins known as WNT9A and FZD9. By examining how these proteins interact with each other and their receptors on cell surfaces, the study aims to uncover the processes that lead to various cellular functions such as growth and maintenance. The research employs advanced techniques to track how these proteins are internalized by cells and how this affects gene activity within the cell nucleus. Understanding these signaling pathways could provide insights into fundamental biological processes and potential disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to cellular signaling abnormalities.
Not a fit: Patients with conditions unrelated to cell signaling or those who do not exhibit any cellular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to cell signaling dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding similar signaling pathways, indicating that this approach has potential for success.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Grainger, Stephanie Laura — Van Andel Research Institute
- Study coordinator: Grainger, Stephanie Laura
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.