Exploring how viruses interact with chromatin in cells
Investigating chromatin mechanisms using viral systems
This study is looking at how certain viruses, like adenoviruses and herpesviruses, use the way our DNA is organized in cells to help them multiply, which could help us learn more about how this process works and its links to diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10842160 on NIH RePORTER |
What this research studies
This research investigates the role of chromatin, the structure that organizes DNA in cells, in the context of viral infections. By using advanced techniques to study how viruses manipulate chromatin, the research aims to uncover the dynamic interactions that occur during viral replication. The approach focuses on specific viruses, such as adenoviruses and herpesviruses, to identify how they exploit chromatin for their benefit. This could lead to a better understanding of chromatin's biological functions and its implications in diseases, particularly cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers that may be influenced by viral infections or chromatin dysregulation.
Not a fit: Patients with non-cancerous conditions unrelated to viral infections or chromatin abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into cancer treatment by revealing how viruses interact with chromatin, potentially identifying new therapeutic targets.
How similar studies have performed: Other research has shown success in understanding virus-host interactions and their implications in molecular biology, suggesting that this approach has the potential for significant findings.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Avgousti, Daphne Christina — Fred Hutchinson Cancer Center
- Study coordinator: Avgousti, Daphne Christina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.