Exploring how viruses interact with bacteria
Discovery of novel phage-bacterial interactions
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-11004987
This study is looking at how bacteria and their viruses work together, which could help us learn more about how bacteria defend themselves and how we might use these viruses to improve treatments for bacterial infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11004987 on ClinicalTrials.gov |
What this research studies
This research investigates the interactions between bacteria and their viruses, known as phages, to uncover new bacterial immune systems and their mechanisms. By using advanced techniques like yeast two-hybrid screens and mass spectrometry, the study aims to identify phage proteins that can either activate or inhibit bacterial immune responses. This could lead to a better understanding of bacterial defenses and how phages can be used in genetic engineering and therapeutic applications. Patients may benefit from insights gained in this research, particularly in the context of bacterial infections and treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit include individuals with bacterial infections or those interested in cutting-edge genetic therapies.
Not a fit: Patients with viral infections unrelated to bacterial interactions may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments for bacterial infections and advancements in genetic engineering.
How similar studies have performed: Other research has shown success in understanding phage-bacterial interactions, particularly in the development of CRISPR technology, indicating a promising avenue for further exploration.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MARINO, NICOLE D. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: MARINO, NICOLE D.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.