Exploring how viral infections affect Alzheimer's disease and brain inflammation
Investigating the interactions between viral infection, Tau pathology, and neuroinflammation
['FUNDING_OTHER'] · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · NIH-10746267
This study is looking at how viral infections might affect the brain and contribute to Alzheimer's disease, using mice to see how these infections can change a protein linked to the disease, with the hope of learning more about how the immune system plays a role in Alzheimer's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF NORTH CAROLINA CHARLOTTE (nih funded) |
| Locations | 1 site (CHARLOTTE, UNITED STATES) |
| Trial ID | NIH-10746267 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between viral infections and Alzheimer's disease, focusing on how these infections may contribute to neuroinflammation and Tau pathology in the brain. Using a mouse model, the study will examine how viral infections can lead to changes in Tau protein, which is associated with Alzheimer's disease. The researchers aim to understand the mechanisms behind these interactions, which could provide insights into the role of the immune system in Alzheimer's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with a history of viral infections or neuroinflammatory conditions.
Not a fit: Patients who do not have Alzheimer's disease or related neurodegenerative conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating Alzheimer's disease by targeting viral infections and neuroinflammation.
How similar studies have performed: Other research has shown promising results in understanding the role of neuroinflammation in Alzheimer's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
CHARLOTTE, UNITED STATES
- UNIVERSITY OF NORTH CAROLINA CHARLOTTE — CHARLOTTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FUNK, KRISTEN EMILY — UNIVERSITY OF NORTH CAROLINA CHARLOTTE
- Study coordinator: FUNK, KRISTEN EMILY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease