Exploring how vagus nerve stimulation can improve movement after chronic stroke
Mechanisms of paired vagus nerve stimulation in human chronic stroke
This study is looking at how using a special device to stimulate a nerve in the neck, along with rehabilitation exercises, can help people who have had a stroke regain better movement in their arms and hands.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10827024 on NIH RePORTER |
What this research studies
This research investigates the use of vagus nerve stimulation (VNS) combined with rehabilitation training to enhance recovery of upper extremity motor function in individuals who have experienced a chronic stroke. The approach involves delivering electrical stimulation to the cervical vagus nerve during specific training movements, which has shown promise in animal models for promoting brain plasticity and improving motor skills. The study aims to understand the mechanisms behind this therapy in humans and identify which patients may benefit the most, potentially leading to more effective treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a chronic stroke and are facing upper extremity motor impairments.
Not a fit: Patients who have not had a stroke or those with acute stroke conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved rehabilitation techniques for stroke survivors, enhancing their ability to regain motor function.
How similar studies have performed: Previous studies have shown some success with vagus nerve stimulation in animal models and early clinical trials, but this specific approach in chronic stroke patients is still being explored.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Schambra, Heidi — New York University School of Medicine
- Study coordinator: Schambra, Heidi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.