Exploring how Ulp1 helps repair DNA damage in specific regions of chromosomes
Official title: Understanding the Role of Ulp1 as a clock for heterochromatin repair
Funded at University of Southern California · NIH-10999061 · Data updated 2026-11-12
This study is looking at how a specific protein helps fix broken DNA in certain areas of our genes, which is important for keeping our DNA healthy, and it aims to find out why some people might be more affected by DNA damage, especially in relation to cancer and genetic disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | August 5, 2024 |
| Project end | August 4, 2027 |
| Funding year | 2024 |
| Award (this year) | $45,171 |
| NIH project number | 1F31ES036878-01 |
| Project ID | NIH-10999061 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of cancer or genetic disorders related to DNA repair deficiencies.
✕Less likely to help
Patients who do not have issues related to DNA damage or repair, such as those without a history of cancer or genetic predispositions, may not benefit from this research.
What this research studies
This research investigates the mechanisms by which Ulp1 contributes to the repair of double-strand breaks in heterochromatin, a dense form of DNA that is crucial for maintaining genome stability. Using a model system of fruit fly cells, the study aims to understand how DNA damage occurs and how it can be effectively repaired, particularly in cancer and other genetic disorders. The research will also extend to mouse and human cells to identify conserved pathways that may be targeted for therapeutic interventions. By examining the molecular processes involved, the study seeks to uncover why some individuals are more sensitive to DNA damage than others.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for improving DNA repair mechanisms, potentially reducing cancer risk and enhancing treatment outcomes.
How similar studies have gone: Previous research has shown success in understanding DNA repair mechanisms in model organisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Butova, Nadejda — University of Southern California
- Study coordinator: Butova, Nadejda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.